Cancer risk

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1-year risks of cancers associated with COVID-19 vaccination: a large population-based cohort study in South Korea

https://www.thefocalpoints.com/p/breaking-second-massive-population
https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-025-00831-w

Large-scale population-based retrospective study in South Korea

To estimate the cumulative incidences and subsequent risks of overall cancers 1 year after COVID-19 vaccination.

Data N= 8,407,849

Between 2021 and 2023

Korean National Health Insurance database.

The participants were categorized into two groups based on their COVID-19 vaccination status.

Cancers significantly increased, 1 year post-vaccination

Thyroid HR, 1.351
(95% CI, 1.206–1.514)

Gastric HR, 1.335
(95% CI, 1.130–1.576)

Colorectal HR, 1.283
(95% CI, 1.122–1.468)

Lung HR, 1.533
(95% CI, 1.254–1.874)

Breast HR, 1.197
(95% CI, 1.069–1.340)

Prostate HR, 1.687
(95% CI, 1.348–2.111)

cDNA vaccines

Associated with the increased risks of:

Thyroid, gastric, colorectal, lung, prostate cancers

mRNA vaccines

Linked to the increased risks of:

Thyroid, colorectal, lung, breast cancers

Heterologous vaccination

Related to the increased risks of:

Thyroid, breast cancers.

Observed associations between COVID-19 vaccination and cancer incidence

Vaccinated men

More vulnerable to gastric and lung cancers

Vaccinated women

More susceptible to thyroid and colorectal cancers.

Population under 65

More vulnerable to thyroid and breast cancers

Population over 75

More susceptible to prostate cancer

COVID-19 vaccination-associated cancer risk was likely more elevated among individuals aged ≤ 65

(except prostate cancer)

Booster doses

Gastric and pancreatic cancers
Mechanisms from the paper
Renin–angiotensin–aldosterone system
Mutagenicity
Inflammatory cascade
Underlying molecular mechanisms

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