Dominik Wodarz - Evolution in Spatially Structured Tumors, Pt. 2/2 - IPAM at UCLA
Recorded 23 February 2026. Dominik Wodarz of the University of California, San Diego, presents "volution in Spatially Structured Tumors, Pt. 2/2" at IPAM's Mathematics of Cancer: Open Mathematical Problems Workshop.Abstract: Spatial organization is a fundamental feature of tumor architecture that profoundly shapes cellular evolution and selection. This lecture examines how spatial structure influences evolutionary dynamics, with implications for driver mutation selection, tumor progression, and therapeutic resistance. I will begin by surveying spatially explicit computational modeling approaches for cellular dynamics and evolution, emphasizing the relationship between continuous-space agent-based models and coarse-grained deme models that enable analytical tractability. Through selected studies, I will explore mutant evolution in spatially structured populations, first examining expanding populations across different dimensions, then investigating mutant invasion at steady state, which is relevant for both non-neoplastic tissue and tumors in growth plateau phases during multi-step carcinogenesis. I will close by discussing our recent finding that spatial structure can reverse conventional selection: mutants with increased reproductive output may experience negative selection when multiple kinetic parameters change simultaneously, for instance, concurrent increases in both division and death rates. This challenges the assumption that higher reproductive output confers advantage. Overall, the lecture highlights how spatial population structure can fundamentally alter evolutionary principles in unexpected ways, deepening our understanding of tumor cell emergence during progression and therapy.
Learn more online at: https://www.ipam.ucla.edu/programs/workshops/mathematics-of-cancer-open-mathematical-problems/ Receive SMS online on sms24.me
TubeReader video aggregator is a website that collects and organizes online videos from the YouTube source. Video aggregation is done for different purposes, and TubeReader take different approaches to achieve their purpose.
Our try to collect videos of high quality or interest for visitors to view; the collection may be made by editors or may be based on community votes.
Another method is to base the collection on those videos most viewed, either at the aggregator site or at various popular video hosting sites.
TubeReader site exists to allow users to collect their own sets of videos, for personal use as well as for browsing and viewing by others; TubeReader can develop online communities around video sharing.
Our site allow users to create a personalized video playlist, for personal use as well as for browsing and viewing by others.
@YouTubeReaderBot allows you to subscribe to Youtube channels.
By using @YouTubeReaderBot Bot you agree with YouTube Terms of Service.
Use the @YouTubeReaderBot telegram bot to be the first to be notified when new videos are released on your favorite channels.
Look for new videos or channels and share them with your friends.
You can start using our bot from this video, subscribe now to Dominik Wodarz - Evolution in Spatially Structured Tumors, Pt. 2/2 - IPAM at UCLA
What is YouTube?
YouTube is a free video sharing website that makes it easy to watch online videos. You can even create and upload your own videos to share with others. Originally created in 2005, YouTube is now one of the most popular sites on the Web, with visitors watching around 6 billion hours of video every month.
