Parkinson’s Expert on the Science of High-Intensity Exercise

In this episode of the CrossFit Podcast, host Jocelyn Rylee sits down with Michelle Hespeler and Dr. Sule Tinaz of Yale School of Medicine to explore the science and lived experience behind high-intensity exercise for Parkinson’s disease.

Hespeler was diagnosed with Parkinson’s at age 40. A former physical education teacher, she began experimenting with structured, high-effort training long before exercise was widely discussed as part of Parkinson’s care. Tinaz is a neuroscientist and movement disorders specialist whose research focuses on how exercise affects the brain itself.

Together, they share results from a pilot study using MRI and PET imaging that showed increased dopaminergic signals after six months of high-intensity exercise. They unpack what those brain changes may mean, why effort matters more than perfection, and how exercise can improve movement, cognition, independence, and quality of life. Receive SMS online on sms24.me

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